⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175846 | 0.94 | — | — | |
| SCHEMBL212537 | 0.85 | MAPK1 (0.36) | — | |
| SCHEMBL24252985 | 0.79 | ALDH1A1 (0.31) | — | |
| SCHEMBL16264308 | 0.78 | ALDH1A1 (0.39) | — | |
| SCHEMBL15437113 | 0.78 | ALDH1A1 (0.39) | — | |
| SCHEMBL947476 | 0.78 | — | — | |
| SCHEMBL5665742 | 0.77 | ALDH1A1 (0.50) | — | |
| SCHEMBL14182576 | 0.76 | — | — | |
| SCHEMBL7424822 | 0.76 | MAPK1 (0.33) | — | |
| SCHEMBL7424817 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9561285-B2 | Carrier-linked carbamate prodrug linkers | ASCENDIS PHARMA AS (DK) | 2017-02-07 | — | — | US | disclosed |
| US-9457066-B2 | Prodrugs comprising an insulin linker conjugate | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2016-10-04 | — | — | US | disclosed |
| US-9278139-B2 | Sterilization of biodegradable hydrogels | ASCENDIS PHARMA A/S (DK) | 2016-03-08 | — | — | US | disclosed |
| US-9138462-B2 | Prodrugs comprising an insulin linker conjugate | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2015-09-22 | — | — | US | disclosed |
| US-20150258207-A1 | PRODRUGS COMPRISING AN INSULIN LINKER CONJUGATE | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2015-09-17 | — | — | US | disclosed |
| US-9133276-B2 | Prodrugs comprising an exendin linker conjugate | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2015-09-15 | — | — | US | disclosed |
| US-20150196667-A1 | STERILIZATION OF BIODEGRADABLE HYDROGELS | ASCENDIS PHARMA AS (DK) | 2015-07-16 | — | — | US | disclosed |
| US-9062094-B2 | Dipeptide-based prodrug linkers for aliphatic amine-containing drugs | ASCENDIS PHARMA AS (DK) | 2015-06-23 | — | — | US | disclosed |
| US-8986609-B2 | Sterilization of biodegradable hydrogels | ASCENDIS PHARMA A/S (DK) | 2015-03-24 | — | — | US | disclosed |
| US-20130035635-A1 | CARRIER-LINKED CARBAMATE PRODRUG LINKERS | ASCENDIS PHARMA A/S (DK) | 2013-02-07 | — | — | US | disclosed |
| US-20120253071-A1 | Sterilization of biodegradable hydrogels | ASCENDIS PHARMA A/S (DK) | 2012-10-04 | — | — | US | disclosed |
| US-20120191039-A1 | CARRIER LINKED PRAMIPEXOLE PRODRUGS | ASCENDIS PHARMA A/S (DK) | 2012-07-26 | — | — | US | disclosed |
| US-20120183616-A1 | LONG ACTING INSULIN COMPOSITION | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2012-07-19 | — | — | US | disclosed |
| US-20120184489-A1 | PRODRUGS COMPRISING AN INSULIN LINKER CONJUGATE | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2012-07-19 | — | — | US | disclosed |
| US-20120156259-A1 | Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels | ASCENDIS PHARMA A/S (DK) | 2012-06-21 | — | — | US | disclosed |