Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 16/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28231611 | 0.88 | CCR2 (0.68) | CCR2PKMBRAFALDH1A1 | |
| SCHEMBL28231615 | 0.86 | CCR2 (0.65) | CCR2PKMBRAFALDH1A1 | |
| SCHEMBL9930868 | 0.84 | CCR2 (0.73) | CCR2PKMBRAF | |
| SCHEMBL9930779 | 0.84 | CCR2 (0.73) | CCR2PKMBRAF | |
| SCHEMBL9930917 | 0.84 | CCR2 (0.76) | CCR2PKMBRAF | |
| SCHEMBL9930692 | 0.82 | CCR2 (0.78) | CCR2PKMBRAF | |
| SCHEMBL9968044 | 0.82 | CCR2 (0.73) | CCR2PKMBRAF | |
| SCHEMBL19406113 | 0.82 | CCR2 (0.73) | CCR2PKMBRAF | |
| SCHEMBL9931058 | 0.82 | CCR2 (0.77) | CCR2PKMBRAF | |
| SCHEMBL9931481 | 0.82 | CCR2 (0.77) | CCR2PKMBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580779-B2 | 1,2-bis-sulfonamide derivatives as chemokine receptor modulators | ALLERGAN, INC. (US) | 2013-11-12 | — | — | US | disclosed |
| US-20120157444-A1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157444-A1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | CXCR2, CCR2, CX3CR1 | CCR2 2/4885PKM 3507/4885BRAF 1188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.