Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pki-166. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 19/20 | 1.00 |
| ▸ | CSF1R | P07333 | 1/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.74 |
| ▸ | KDR | P35968 | 1/20 | 0.74 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.74 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.74 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.74 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.74 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.74 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.74 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pki-166 SCHEMBL185822 | 1.00 | EGFR (1.00) | EGFRCSF1RHDAC3KDRHDAC4 | |
| Pki-166 SCHEMBL30883827 | 1.00 | EGFR (1.00) | EGFRCSF1RHDAC3KDRHDAC4 | |
| Pki-166 SCHEMBL29352405 | 1.00 | EGFR (1.00) | EGFRCSF1RHDAC3KDRHDAC4 | |
| Pki-166 SCHEMBL209560 | 1.00 | EGFR (1.00) | EGFRCSF1RHDAC3KDRHDAC4 | |
| Pki-166 SCHEMBL29409570 | 0.99 | EGFR (0.98) | EGFRCSF1RHDAC3KDRHDAC4 | |
| SCHEMBL12308303 | 0.89 | EGFR (0.86) | EGFRCSF1RHDAC3KDRHDAC4 | |
| SCHEMBL4766235 | 0.89 | EGFR (0.86) | EGFRCSF1RHDAC3KDRHDAC4 | |
| SCHEMBL4766237 | 0.89 | EGFR (0.86) | EGFRCSF1RHDAC3KDRHDAC4 | |
| SCHEMBL7499430 | 0.89 | EGFR (0.86) | EGFRCSF1RHDAC3KDRHDAC4 | |
| SCHEMBL4901987 | 0.89 | EGFR (1.00) | EGFRHDAC3KDRHDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130204238-A1 | COMBINATION THERAPY | FOLLICA, INC (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130204238-A1 | COMBINATION THERAPY | FOLLICA, INC (US) | 2013-08-08 | — | — | US | disclosed |
| US-8252749-B2 | Methods, kits, and compositions for generating new hair follicles and growing hair | FOLLICA, INC. (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252749-B2 | Methods, kits, and compositions for generating new hair follicles and growing hair | FOLLICA, INC. (US) | 2012-08-28 | — | — | US | disclosed |
| US-20120156228-A1 | Methods, Kits, and Compositions for Generating New Hair Follicles and Growing Hair | FOLLICA, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120156228-A1 | Methods, Kits, and Compositions for Generating New Hair Follicles and Growing Hair | FOLLICA, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| US-20110130706-A1 | SEQUENTIAL BODY SURFACE TREATMENT | FOLLICA, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| US-20110130706-A1 | SEQUENTIAL BODY SURFACE TREATMENT | FOLLICA, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| US-20110130711-A1 | HAIR GROWTH TREATMENT | FOLLICA, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| US-20110130711-A1 | HAIR GROWTH TREATMENT | FOLLICA, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| US-20110130748-A1 | BODY SURFACE TREATMENT | FOLLICA, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| US-20110130748-A1 | BODY SURFACE TREATMENT | FOLLICA, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| US-20100298760-A1 | METHODS, KITS, AND COMPOSITIONS FOR ADMINISTERING PHARMACEUTICAL COMPOUNDS | PURETECH VENTURES | 2010-11-25 | — | — | US | disclosed |
| US-20100298760-A1 | METHODS, KITS, AND COMPOSITIONS FOR ADMINISTERING PHARMACEUTICAL COMPOUNDS | PURETECH VENTURES | 2010-11-25 | — | — | US | disclosed |
| US-20100120768-A1 | METHODS, KITS, AND COMPOSITIONS FOR GENERATING NEW HAIR FOLLICLES AND GROWING HAIR | LIGHTHOUSE CAPITAL PARTNERS VI, L.P. | 2010-05-13 | — | — | US | disclosed |
| US-20100120768-A1 | METHODS, KITS, AND COMPOSITIONS FOR GENERATING NEW HAIR FOLLICLES AND GROWING HAIR | LIGHTHOUSE CAPITAL PARTNERS VI, L.P. | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120768-A1 | METHODS, KITS, AND COMPOSITIONS FOR GENERATING NEW HAIR FOLLICLES AND GROWING HAIR | NGF, HDGF, SHH | EGFR 85/4885CSF1R 1717/4885HDAC3 2419/4885 |
| US-20120156228-A1 | Methods, Kits, and Compositions for Generating New Hair Follicles and Growing Hair | NGF, HDGF, SHH | EGFR 85/4885CSF1R 1717/4885HDAC3 2419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.