Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.49 |
| ▸ | XIAP | P98170 | 7/20 | 0.46 |
| ▸ | BIRC3 | Q13489 | 2/20 | 0.46 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.42 |
| ▸ | PREP | P48147 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9973467 | 1.00 | CASP1 (0.49) | CASP1XIAPBIRC3BIRC2KMT2A | |
| SCHEMBL31384817 | 1.00 | CASP1 (0.49) | CASP1XIAPBIRC3BIRC2KMT2A | |
| SCHEMBL31384849 | 0.94 | CASP1 (0.48) | CASP1XIAPBIRC3BIRC2KMT2A | |
| SCHEMBL31384833 | 0.88 | CASP1 (0.46) | CASP1XIAPBIRC2KMT2AL3MBTL1 | |
| SCHEMBL25873179 | 0.88 | CASP1 (0.56) | CASP1XIAPBIRC3BIRC2KMT2A | |
| SCHEMBL9973474 | 0.88 | CASP1 (0.54) | CASP1XIAPBIRC3BIRC2KMT2A | |
| SCHEMBL31384887 | 0.88 | CASP1 (0.46) | CASP1XIAPKMT2AL3MBTL1CASP3 | |
| SCHEMBL9973468 | 0.86 | CASP1 (0.48) | CASP1XIAPKMT2AL3MBTL1CASP3 | |
| SCHEMBL22515895 | 0.86 | CASP1 (0.45) | CASP1XIAPKMT2AL3MBTL1CASP3 | |
| SCHEMBL1299623 | 0.85 | CASP1 (0.47) | CASP1XIAPKMT2AL3MBTL1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220185831-A1 | STAT3 PROTEIN DEGRADERS | UNIV MICHIGAN REGENTS (US) | 2022-06-16 | — | — | US | disclosed |
| WO-2020205467-A1 | STAT3 PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-10-08 | — | — | WO | disclosed |
| US-8202902-B2 | Bivalent SMAC mimetics and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-06-19 | — | — | US | disclosed |
| US-7960372-B2 | Inhibitors of apoptosis proteins; antiproliferative agents; kits | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-06-14 | — | — | US | disclosed |
| US-20090123480-A1 | BIVALENT SMAC MIMETICS AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-14 | — | — | US | disclosed |
| US-20090123480-A1 | BIVALENT SMAC MIMETICS AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-14 | — | — | US | disclosed |
| US-20080089896-A1 | Bivalent SMAC mimetics and the uses thereof | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-04-17 | — | — | US | disclosed |
| US-20080089896-A1 | Bivalent SMAC mimetics and the uses thereof | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-04-17 | — | — | US | disclosed |
| WO-2007130626-A2 | BIVALENT SMAC MIMETICS AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185831-A1 | STAT3 PROTEIN DEGRADERS | STAT3, JAK2, STAT5A | CASP1 2478/4885XIAP 1955/4885BIRC3 4377/4885 |
| US-20080089896-A1 | Bivalent SMAC mimetics and the uses thereof | BID, BAD, BIRC2 | CASP1 189/4885XIAP 22/4885BIRC3 6/4885 |
| US-20090123480-A1 | BIVALENT SMAC MIMETICS AND THE USES THEREOF | BID, BAD, BIRC2 | CASP1 189/4885XIAP 22/4885BIRC3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.