Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | MMP7 | P09237 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12898934 | 0.89 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AFKBP1ACYP2C19 | |
| SCHEMBL25408531 | 0.86 | FKBP1A (0.51) | SMN1; SMN2NPC1RAB9AFKBP1ACYP2C19 | |
| SCHEMBL25408533 | 0.86 | FKBP1A (0.51) | SMN1; SMN2NPC1RAB9AFKBP1ACYP2C19 | |
| SCHEMBL9973549 | 0.86 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9ACYP2C19HTT | |
| SCHEMBL9973491 | 0.85 | XIAP (0.53) | XIAPBIRC2 | |
| SCHEMBL9975069 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AFKBP1ACYP2C19 | |
| SCHEMBL9973551 | 0.82 | XIAP (0.46) | SMN1; SMN2NPC1RAB9AFKBP1AHTT | |
| SCHEMBL9973493 | 0.82 | XIAP (0.46) | SMN1; SMN2NPC1RAB9AFKBP1AHTT | |
| SCHEMBL6111141 | 0.80 | CASP1 (0.51) | SMN1; SMN2NPC1RAB9AFKBP1ACYP2C19 | |
| SCHEMBL13453701 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AFKBP1ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2019671-B1 | INTERMEDIATES FOR THE PREPARATION OF BIVALENT SMAC MIMETICS | UNIV MICHIGAN (US) | 2014-09-24 | — | — | EP | disclosed |
| US-8202902-B2 | Bivalent SMAC mimetics and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-06-19 | — | — | US | disclosed |
| US-8202902-B2 | Bivalent SMAC mimetics and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-06-19 | — | — | US | disclosed |
| US-7960372-B2 | Inhibitors of apoptosis proteins; antiproliferative agents; kits | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-06-14 | — | — | US | disclosed |
| US-7960372-B2 | Inhibitors of apoptosis proteins; antiproliferative agents; kits | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-06-14 | — | — | US | disclosed |
| US-20090123480-A1 | BIVALENT SMAC MIMETICS AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-14 | — | — | US | disclosed |
| US-20090123480-A1 | BIVALENT SMAC MIMETICS AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-14 | — | — | US | disclosed |
| US-20080089896-A1 | Bivalent SMAC mimetics and the uses thereof | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-04-17 | — | — | US | disclosed |
| US-20080089896-A1 | Bivalent SMAC mimetics and the uses thereof | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-04-17 | — | — | US | disclosed |
| WO-2007130626-A2 | BIVALENT SMAC MIMETICS AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080089896-A1 | Bivalent SMAC mimetics and the uses thereof | BID, BAD, BIRC2 | SMN1; SMN2 193/4885NPC1 4724/4885RAB9A 4113/4885 |
| US-20090123480-A1 | BIVALENT SMAC MIMETICS AND THE USES THEREOF | BID, BAD, BIRC2 | SMN1; SMN2 193/4885NPC1 4724/4885RAB9A 4113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.