Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.55 |
| ▸ | FGB | P02675 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15116313 | 0.92 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9974116 | 0.90 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9974127 | 0.88 | MEN1 (0.61) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9974087 | 0.88 | MEN1 (0.61) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9974102 | 0.85 | MEN1 (0.59) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL1091775 | 0.85 | SCN3A (0.64) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9972277 | 0.81 | LMNA (0.59) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9974111 | 0.80 | LMNA (0.57) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL12522877 | 0.80 | ALDH1A1 (0.62) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9972245 | 0.80 | MAPT (0.60) | ALDH1A1MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309543-B2 | Compositions useful as inhibitors of voltage-gated sodium channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-13 | — | — | US | disclosed |
| US-8202861-B2 | Drugs for various disorders | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-19 | — | — | US | disclosed |