Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.30 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9974154 | 0.85 | GPR119 (0.40) | GPR119SIGMAR1CHRM2CHRM4CHRM5 | |
| SCHEMBL9937022 | 0.84 | GPR119 (0.49) | GPR119 | |
| SCHEMBL9936855 | 0.78 | CHRNB2 (0.37) | GPR119 | |
| SCHEMBL15007877 | 0.77 | GPR119 (0.48) | GPR119 | |
| SCHEMBL17707522 | 0.73 | GPR119 (0.72) | GPR119 | |
| SCHEMBL17707519 | 0.73 | GPR119 (0.72) | GPR119 | |
| SCHEMBL14316412 | 0.70 | GPR119 (0.45) | GPR119 | |
| SCHEMBL9935783 | 0.70 | GPR119 (0.48) | GPR119 | |
| SCHEMBL4555482 | 0.66 | GPR119 (0.46) | GPR119CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2595921 | 0.66 | KMT2A (0.37) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013083775-A1 | NEW COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-13 | — | — | WO | disclosed |
| WO-2012080476-A1 | FUSED DIHYDROPYRANS AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY AND RELATED DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-21 | — | — | WO | disclosed |