Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9974216 | 0.88 | GPR119 (0.49) | GPR119CCNCCDK8HASPINNAMPT | |
| SCHEMBL14244633 | 0.87 | GPR119 (0.59) | GPR119 | |
| SCHEMBL9974166 | 0.82 | GPR119 (0.55) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL9936801 | 0.81 | GPR119 (0.57) | GPR119 | |
| SCHEMBL9943189 | 0.79 | GPR119 (0.60) | GPR119 | |
| SCHEMBL9943209 | 0.79 | GPR119 (0.49) | GPR119 | |
| SCHEMBL9974202 | 0.79 | GPR119 (0.62) | GPR119CCNCCDK8HASPINNAMPT | |
| SCHEMBL9974189 | 0.78 | GPR119 (0.48) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL9974232 | 0.78 | GPR119 (0.45) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL9943227 | 0.78 | GPR119 (0.55) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012080476-A1 | FUSED DIHYDROPYRANS AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY AND RELATED DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-21 | — | — | WO | disclosed |