Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 16/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.37 |
| ▸ | CLK3 | P49761 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17715352 | 0.88 | GPR119 (0.44) | GPR119 | |
| SCHEMBL15025841 | 0.88 | GPR119 (0.44) | GPR119 | |
| SCHEMBL14244580 | 0.88 | GPR119 (0.57) | GPR119 | |
| SCHEMBL14244581 | 0.88 | GPR119 (0.57) | GPR119 | |
| SCHEMBL9974194 | 0.82 | GPR119 (0.49) | GPR119FAAH | |
| SCHEMBL15541026 | 0.80 | GPR119 (0.48) | GPR119 | |
| SCHEMBL15583171 | 0.80 | GPR119 (0.48) | GPR119 | |
| SCHEMBL18286848 | 0.78 | GPR119 (0.35) | GPR119 | |
| SCHEMBL14244872 | 0.77 | GPR119 (0.58) | GPR119 | |
| SCHEMBL9937286 | 0.77 | GPR119 (0.58) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012080476-A1 | FUSED DIHYDROPYRANS AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY AND RELATED DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-21 | — | — | WO | disclosed |