⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19068069 | 0.77 | APLNR (0.32) | — | |
| SCHEMBL24600847 | 0.77 | APLNR (0.32) | — | |
| SCHEMBL9965013 | 0.75 | — | — | |
| SCHEMBL12508939 | 0.71 | — | — | |
| SCHEMBL18760647 | 0.71 | PLAU (0.33) | — | |
| SCHEMBL25595377 | 0.70 | — | — | |
| SCHEMBL20099129 | 0.69 | CCR1 (0.31) | — | |
| SCHEMBL10020527 | 0.69 | APLNR (0.32) | — | |
| SCHEMBL7702027 | 0.69 | APLNR (0.32) | — | |
| SCHEMBL19185569 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120277219-A1 | NOVEL PYRIDOPYRAZINE DERIVATIVES, PROCESS OF MANUFACTURING AND USES THEREOF | AETERNA ZENTARIS GMBH (DE) | 2012-11-01 | — | — | US | disclosed |
| US-20120209050-A1 | NOVEL PYRIDOPYRAZINE DERIVATIVES, PROCESS OF MANUFACTURING AND USES THEREOF | AETERNA ZENTARIS GMBH (DE) | 2012-08-16 | — | — | US | disclosed |
| US-8202883-B2 | Substituted pyrido[2,3-b]pyrazine compounds as modulators of tyrosine kinases | AETERNA ZENTARIS GMBH (DE) | 2012-06-19 | — | — | US | disclosed |
| US-20090275534-A1 | NOVEL PYRIDOPYRAZINE DERIVATIVES, PROCESS OF MANUFACTURING AND USES THEREOF | ZENTARIS GMBH (DE) | 2009-11-05 | — | — | US | disclosed |