Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 3/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9964954 | 0.83 | SMN1; SMN2 (0.35) | LMNAMAPK1HTTATMNPSR1 | |
| SCHEMBL9966000 | 0.81 | PARP1 (0.43) | HTTL3MBTL1ATMMAPTSMN1; SMN2 | |
| SCHEMBL14042054 | 0.77 | KAT6A (0.36) | LMNAMAPK1HTTALDH1A1MAPT | |
| SCHEMBL214249 | 0.76 | LMNA (0.42) | LMNAL3MBTL1ATMNPSR1MAOA | |
| Methane SCHEMBL756715 | 0.74 | LMNA (0.40) | LMNAL3MBTL1ATMNPSR1MAOA | |
| SCHEMBL280538 | 0.74 | ELANE (0.47) | LMNAATMELANENPSR1CES2 | |
| SCHEMBL12798154 | 0.73 | BLM (0.42) | LMNAL3MBTL1MAOAMAOBCES2 | |
| SCHEMBL3385461 | 0.71 | ELANE (0.54) | LMNAHTTATMELANENPSR1 | |
| SCHEMBL8360174 | 0.71 | NOS3 (0.43) | LMNAMAPK1HTTL3MBTL1ATM | |
| SCHEMBL12171994 | 0.70 | TSHR (0.45) | CES2CES1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012080236-A1 | 6-SUBSTITUTED IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-21 | — | — | WO | disclosed |