Quinoxaline

Quinoxaline

SCHEMBL997539

COS(=O)(=O)OC.c1ccc2nccnc2c1.c1ccc2nccnc2c1

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTT P42858 3/20 0.39
POLB P06746 3/20 0.39
PKM P14618 1/20 0.39
ALDH1A1 P00352 3/20 0.38
TGFBR1 P36897 3/20 0.37
MAPT P10636 3/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
KMT2A Q03164 3/20 0.35
MEN1 O00255 2/20 0.35
LMNA P02545 1/20 0.35
GAA P10253 1/20 0.35
ALOX5AP P20292 1/20 0.34
FEN1 P39748 1/20 0.34
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA9 Q16790 1/20 0.34
NQO2 P16083 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinoxaline SCHEMBL16054065 0.85 POLB (0.38) HTTPOLBPKMALDH1A1MAPT
Quinoxaline SCHEMBL10435186 0.85 POLB (0.38) HTTPOLBPKMALDH1A1MAPT
Quinoline SCHEMBL9565056 0.84 ALDH1A1 (0.63) HTTPOLBALDH1A1MAPTSMN1; SMN2
Phenazine SCHEMBL11515965 0.82 MAPT (0.52) HTTPOLBPKMALDH1A1MAPT
Phenazine SCHEMBL28246501 0.80 MAPT (0.50) HTTPOLBPKMALDH1A1MAPT
Quinoxaline SCHEMBL4270011 0.77 ALDH1A1 (0.44) HTTPOLBALDH1A1MAPTSMN1; SMN2
Quinoxaline SCHEMBL27732327 0.77 ALDH1A1 (0.44) HTTPOLBALDH1A1MAPTSMN1; SMN2
Quinoxaline SCHEMBL30320908 0.75 ALDH1A1 (0.58) POLBALDH1A1MAPTKMT2AMEN1
Quinoxaline SCHEMBL5315 0.75 ALDH1A1 (0.58) POLBALDH1A1MAPTKMT2AMEN1
Quinoxaline SCHEMBL29355228 0.75 ALDH1A1 (0.58) POLBALDH1A1MAPTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4188445-A1 APPLICATION OF DIPYRRINATO-IRIDIUM COMPLEXES IN ANTI-TUMOR AND ANTI-BACTERIAL THERAPY biolitec Unternehmensbeteiligungs II AG (AT) 2023-06-07 EP disclosed
EP-2456435-A1 HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE The Board of Trustees of The Leland Stanford Junior University (US) 2012-05-30 EP disclosed
WO-2011011514-A1 HETEROARYL BENZAMIDES, COMPOSITIONS AND METHODS OF USE THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2011-01-27 WO disclosed
WO-2010078941-A1 CALCIUMPHOSPHATE-BASED NANOPARTICLES AS CARRIER-SYSTEMS FOR PHOTODYNAMIC THERAPY BIOLITEC AG (DE) 2010-07-15 WO disclosed
EP-2084162-A2 BICYCLIC TRIAZOLES AS PROTEIN KINASE MODULATORS SGX Pharmaceuticals, Inc. (US) 2009-08-05 EP disclosed
EP-1966222-A2 PYRAZOLOTHIAZOLE PROTEIN KINASE MODULATORS SGX Pharmaceuticals, Inc. (US) 2008-09-10 EP disclosed
WO-2008051808-A2 BICYCLIC TRIAZOLES AS PROTEIN KINASE MODULATORS SGX PHARMACEUTICALS, INC. (US) 2008-05-02 WO disclosed
WO-2007106236-A2 PYRROLO-PYRIDINE KINASE MODULATORS SGX PHARMACEUTICALS, INC. (US) 2007-09-20 WO disclosed
WO-2007059341-A2 PYRAZOLOTHIAZOLE PROTEIN KINASE MODULATORS SGX PHARMACEUTICALS, INC. (US) 2007-05-24 WO disclosed