Quinoline

Quinoline

SCHEMBL9565056

COS(=O)(=O)OC.c1ccc2ncccc2c1

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.63
NPC1 O15118 3/20 0.46
RAB9A P51151 3/20 0.46
POLB P06746 1/20 0.46
HTT P42858 3/20 0.45
ALOX15 P16050 1/20 0.45
PDGFRB P09619 1/20 0.44
PDGFRA P16234 1/20 0.44
CYP3A4 P08684 2/20 0.40
PDE10A Q9Y233 1/20 0.40
SMN1; SMN2 Q16637 3/20 0.39
LMNA P02545 1/20 0.39
CASP1 P29466 2/20 0.39
KDM4E B2RXH2 2/20 0.39
MEN1 O00255 1/20 0.39
CASP7 P55210 1/20 0.39
KMT2A Q03164 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C19 P33261 1/20 0.39
NR4A2 P43354 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinoline SCHEMBL27764565 0.89 ALDH1A1 (0.63) ALDH1A1NPC1RAB9APOLBHTT
Quinoline SCHEMBL542500 0.87 ALDH1A1 (0.61) ALDH1A1NPC1RAB9APOLBHTT
Quinoline SCHEMBL27595438 0.85 ALDH1A1 (0.46) ALDH1A1NPC1RAB9APOLBHTT
Quinoxaline SCHEMBL997539 0.84 HTT (0.39) ALDH1A1POLBHTTSMN1; SMN2LMNA
Quinoline SCHEMBL27543949 0.84 ALDH1A1 (0.81) ALDH1A1NPC1RAB9APOLBHTT
Quinoline SCHEMBL27422586 0.82 ALDH1A1 (0.85) ALDH1A1NPC1RAB9APOLBHTT
Quinoline SCHEMBL9374715 0.81 ALDH1A1 (0.68) ALDH1A1NPC1RAB9APOLBHTT
Quinoline SCHEMBL1416620 0.81 ALDH1A1 (0.68) ALDH1A1NPC1RAB9APOLBHTT
Quinoline SCHEMBL21535 0.80 ALDH1A1 (0.74) ALDH1A1NPC1RAB9APOLBHTT
Quinoline SCHEMBL259771 0.80 ALDH1A1 (0.74) ALDH1A1NPC1RAB9APOLBHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0531033-A1 Corrosion inhibitor composition EXXON RESEARCH AND ENGINEERING COMPANY (US) 1993-03-10 EP disclosed
US-5158693-A Oligoquinolinium metal oxide salts as sulfur corrosion inhibitors EXXON RESEARCH AND ENGINEERING CO. (US) 1992-10-27 US disclosed