SCHEMBL9975416

SCHEMBL9975416

O=Cc1cc(N(c2ccccc2)c2ccc(-c3ccc(N(c4ccccc4)c4cc(C=O)c5ccccc5c4)cc3)cc2)cc2ccccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APP P05067 2/20 0.41
ERN1 O75460 2/20 0.36
MCL1 Q07820 1/20 0.35
PTPN1 P18031 3/20 0.35
L3MBTL1 Q9Y468 3/20 0.35
PTPN2 P17706 2/20 0.35
ALDH1A1 P00352 4/20 0.34
KDM4E B2RXH2 2/20 0.34
CYP1A2 P05177 2/20 0.34
CYP2C19 P33261 2/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
MAPT P10636 1/20 0.34
CYP2C9 P11712 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
APAF1 O14727 1/20 0.34
CASP3 P42574 1/20 0.34
CASP6 P55212 1/20 0.34
SENP8 Q96LD8 1/20 0.34
SENP7 Q9BQF6 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9973887 0.89 ALDH1A1 (0.41) APPERN1MCL1L3MBTL1ALDH1A1
SCHEMBL9973886 0.80 MAOB (0.38) APPL3MBTL1ALDH1A1KDM4ECYP1A2
SCHEMBL24153801 0.76 ALDH1A1 (0.50) L3MBTL1ALDH1A1KDM4ECYP1A2CYP2C19
SCHEMBL24154650 0.76 ALDH1A1 (0.37) APPL3MBTL1ALDH1A1KDM4ECYP1A2
SCHEMBL30716563 0.76 ERN1 (0.44) ERN1MCL1L3MBTL1ALDH1A1KDM4E
SCHEMBL24153837 0.76 ALDH1A1 (0.49) L3MBTL1ALDH1A1KDM4ECYP1A2CYP2C19
SCHEMBL76512 0.76 ALDH1A1 (0.47) L3MBTL1ALDH1A1KDM4ECYP1A2CYP2C19
SCHEMBL20987819 0.74 MEN1 (0.51) L3MBTL1ALDH1A1KDM4EMAPTTDP1
SCHEMBL20987887 0.74 MEN1 (0.51) L3MBTL1ALDH1A1KDM4EMAPTTDP1
SCHEMBL24153670 0.74 MEN1 (0.51) L3MBTL1ALDH1A1KDM4ECYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8546049-B2 Electrophotographic photoconductor and image forming apparatus using the same SHARP KABUSHIKI KAISHA (JP) 2013-10-01 US disclosed
US-20120156600-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR AND IMAGE FORMING APPARATUS USING THE SAME SHARP KABUSHIKI KAISHA (JP) 2012-06-21 US disclosed