Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9975611 | 0.84 | SREBF2 (0.46) | SMN1; SMN2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL9975609 | 0.83 | HPGD (0.48) | SMN1; SMN2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL8238620 | 0.83 | RARA (0.54) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL8239215 | 0.82 | HPGD (0.51) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL9975610 | 0.82 | SREBF2 (0.56) | SMN1; SMN2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL8239699 | 0.81 | MAPT (0.46) | SMN1; SMN2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL8233212 | 0.80 | HPGD (0.50) | SMN1; SMN2RAB9ANPC1TP53HPGD | |
| SCHEMBL9975607 | 0.78 | CNR2 (0.42) | SMN1; SMN2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL9975602 | 0.78 | MAPT (0.49) | SMN1; SMN2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL11507427 | 0.77 | HDAC1 (0.48) | SMN1; SMN2RAB9ANPC1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394798-B2 | Compositions and methods for inducing neuronal differentiation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-03-12 | — | — | US | disclosed |
| US-20120157457-A1 | COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157457-A1 | COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION | CHAT, DCX, GAP43 | SMN1; SMN2 115/4885RAB9A 2310/4885NPC1 1361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.