Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9975606 | 0.83 | SMN1; SMN2 (0.47) | HPGDSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL8238620 | 0.82 | RARA (0.54) | HPGDSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL9975611 | 0.78 | SREBF2 (0.46) | HPGDSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL9975607 | 0.78 | CNR2 (0.42) | HPGDSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL8239215 | 0.76 | HPGD (0.51) | HPGDSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL9975610 | 0.76 | SREBF2 (0.56) | HPGDSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL12789158 | 0.75 | HPGD (0.69) | HPGDSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL8239699 | 0.75 | MAPT (0.46) | HPGDSMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL8233212 | 0.74 | HPGD (0.50) | HPGDSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL9975602 | 0.73 | MAPT (0.49) | HPGDSMN1; SMN2NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394798-B2 | Compositions and methods for inducing neuronal differentiation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-03-12 | — | — | US | disclosed |
| US-20120157457-A1 | COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157457-A1 | COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2012-06-21 | — | — | US | disclosed |
| US-8105581-B2 | Compositions and methods for inducing neuronal differentiation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-01-31 | — | — | US | disclosed |
| US-20100166710-A1 | Compositions and Methods for Inducing Neuronal Differentiation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100166710-A1 | Compositions and Methods for Inducing Neuronal Differentiation | CHAT, DCX, GAP43 | HPGD 2075/4885SMN1; SMN2 115/4885NPC1 1361/4885 |
| US-20120157457-A1 | COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION | CHAT, DCX, GAP43 | HPGD 2075/4885SMN1; SMN2 115/4885NPC1 1361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.