Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 3/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tt-301 SCHEMBL529969 | 0.82 | CSNK1D (0.60) | CSNK1DMAPK14ALDH1A1TSHRMAPT | |
| SCHEMBL1753099 | 0.82 | CSNK1D (0.60) | CSNK1DMAPK14ALDH1A1TSHRMAPT | |
| Tt-301 SCHEMBL300506 | 0.81 | CSNK1D (0.59) | CSNK1DMAPK14ALDH1A1TSHRMAPT | |
| Tt-301 SCHEMBL9998818 | 0.81 | CSNK1D (0.59) | CSNK1DMAPK14ALDH1A1TSHRMAPT | |
| Tt-301 SCHEMBL529453 | 0.81 | CSNK1D (0.59) | CSNK1DMAPK14ALDH1A1TSHRMAPT | |
| SCHEMBL12706599 | 0.79 | CSNK1D (0.54) | CSNK1DMAPK14ALDH1A1TSHRMAPT | |
| SCHEMBL12706604 | 0.77 | CSNK1D (0.69) | CSNK1DMAPK14ALDH1A1TSHRMAPT | |
| SCHEMBL320404 | 0.77 | CYP1A2 (0.65) | CSNK1DMAPK14ALDH1A1TSHRLMNA | |
| SCHEMBL8908253 | 0.75 | CSNK1D (0.66) | CSNK1DMAPK14ALDH1A1TSHRMAPT | |
| SCHEMBL720267 | 0.75 | SLC6A7 (0.56) | CSNK1DMAPK14ALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157410-A1 | COMPOSITIONS AND TREATMENTS USING PYRIDAZINE COMPOUNDS AND CHOLINESTERASE INHIBITORS | U.S. GOVERNMENT (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157410-A1 | COMPOSITIONS AND TREATMENTS USING PYRIDAZINE COMPOUNDS AND CHOLINESTERASE INHIBITORS | ACHE, BCHE, BACE1 | CSNK1D 912/4885MAPK14 388/4885ALDH1A1 2113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.