SCHEMBL9976289

SCHEMBL9976289

CN(CC(O)CO)C(=O)c1c(I)c(NC(=O)C(O)C(O)CO)c(I)c(C(=O)NCCCNC(=O)c2c(I)c(NC(=O)C(O)C(O)CO)c(I)c(C(=O)N(C)CC(O)CO)c2I)c1I

nearest known ligand 0.58

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.58
CYP2C19 P33261 1/20 0.40
HIF1A Q16665 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3061601 0.96 LMNA (0.55) LMNACYP2C19HIF1A
SCHEMBL3062943 0.95 LMNA (0.58) LMNACYP2C19HIF1A
SCHEMBL13882575 0.95 LMNA (0.54) LMNACYP2C19HIF1A
SCHEMBL13247499 0.94 LMNA (0.55) LMNACYP2C19HIF1A
SCHEMBL10044843 0.94 LMNA (0.55) LMNACYP2C19HIF1A
SCHEMBL13247520 0.93 LMNA (0.53) LMNACYP2C19HIF1A
SCHEMBL10044825 0.92 LMNA (0.56) LMNACYP2C19HIF1ASMN1; SMN2
SCHEMBL13882596 0.91 LMNA (0.54) LMNACYP2C19HIF1A
SCHEMBL13885585 0.91 LMNA (0.60) LMNACYP2C19HIF1ASMN1; SMN2
SCHEMBL13220207 0.91 LMNA (0.67) LMNACYP2C19HIF1ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8202511-B2 Contrast agents GE HEALTHCARE AS (NO) 2012-06-19 US disclosed
US-8202511-B2 Contrast agents GE HEALTHCARE AS (NO) 2012-06-19 US disclosed
US-20100221189-A1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2010-09-02 US disclosed
US-20100221189-A1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2010-09-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100221189-A1 CONTRAST AGENTS NR1I3, NR1I2, NR1D2 LMNA 2753/4885CYP2C19 754/4885HIF1A 612/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.