Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998544 | 0.83 | KDM4E (0.45) | ALPLNPSR1HPGDMAP2K4P2RX7 | |
| SCHEMBL997498 | 0.75 | KDM4E (0.43) | NPSR1HPGDMAP2K4P2RX7ALDH1A1 | |
| SCHEMBL998780 | 0.75 | KDM4E (0.43) | MAP2K4GSK3BSMN1; SMN2KDM4ESTAT3 | |
| SCHEMBL5023203 | 0.69 | TBXA2R (0.45) | ALPLNPSR1P2RX7GSK3BHIF1A | |
| SCHEMBL27956837 | 0.69 | KDM4E (0.58) | MAP2K4ALDH1A1SMN1; SMN2KDM4ESTAT3 | |
| SCHEMBL30609861 | 0.67 | MAP2K4 (0.65) | ALPLMAP2K4GSK3BSMN1; SMN2KDM4E | |
| SCHEMBL4793264 | 0.67 | KDM4E (0.63) | ALPLHPGDMAP2K4ALDH1A1SMN1; SMN2 | |
| SCHEMBL4791992 | 0.67 | MAP2K4 (0.65) | ALPLMAP2K4GSK3BSMN1; SMN2KDM4E | |
| SCHEMBL4109673 | 0.67 | CYP1A2 (0.53) | NPSR1ALDH1A1SMN1; SMN2HIF1ACYP3A4 | |
| SCHEMBL5267750 | 0.66 | NR2E1 (0.37) | NPSR1HPGDP2RX7GSK3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786424-A2 | LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT | The University of Kansas (US) | 2007-05-23 | — | — | EP | claimed |
| WO-2006023704-A2 | LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT | UNIVERSITY OF KANSAS (US) | 2006-03-02 | — | — | WO | claimed |
| EP-2451783-A2 | LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT | University Of Kansas (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005759-A2 | LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT | UNIVERSITY OF KANSAS (US) | 2011-01-13 | — | — | WO | disclosed |