Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 14/20 | 0.58 |
| ▸ | CCR6 | P51684 | 9/20 | 0.57 |
| ▸ | CXCR1 | P25024 | 8/20 | 0.57 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.57 |
| ▸ | CCR4 | P51679 | 3/20 | 0.57 |
| ▸ | CCR7 | P32248 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9978167 | 0.90 | CXCR2 (0.47) | CXCR2CCR6CXCR1CXCR3CCR4 | |
| SCHEMBL9978166 | 0.88 | CCR6 (0.59) | CXCR2CCR6CXCR1CXCR3CCR4 | |
| SCHEMBL9978206 | 0.86 | CXCR2 (0.64) | CXCR2CCR6CXCR1CXCR3CCR4 | |
| SCHEMBL9977987 | 0.85 | CXCR2 (0.59) | CXCR2CCR6CXCR1CXCR3CCR4 | |
| SCHEMBL2296197 | 0.81 | CXCR2 (0.64) | CXCR2CCR6CXCR1CXCR3CCR4 | |
| SCHEMBL15434984 | 0.81 | CXCR2 (0.64) | CXCR2CCR6CXCR1CXCR3CCR4 | |
| SCHEMBL9977980 | 0.81 | CCR6 (0.49) | CXCR2CCR6CXCR1CXCR3CCR4 | |
| SCHEMBL2296199 | 0.81 | CXCR2 (0.64) | CXCR2CCR6CXCR1CXCR3CCR4 | |
| SCHEMBL9978170 | 0.79 | CXCR2 (0.57) | CXCR2CCR6CXCR1CXCR3CCR4 | |
| SCHEMBL9978127 | 0.79 | CXCR2 (0.58) | CXCR2CCR6CXCR1CXCR3CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651932-B1 | BICYCLIC RING SYSTEM SUBSTITUTED SULFONAMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2015-11-25 | — | — | EP | disclosed |
| US-8648070-B2 | Bicyclic ring system substituted sulfonamide functionalised phenols as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-11 | — | — | US | disclosed |
| US-8648070-B2 | Bicyclic ring system substituted sulfonamide functionalised phenols as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-11 | — | — | US | disclosed |
| US-20120316159-A1 | BICYCLIC RING SYSTEM SUBSTITUTED SULFONAMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-12-13 | — | — | US | disclosed |
| US-20120316159-A1 | BICYCLIC RING SYSTEM SUBSTITUTED SULFONAMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-12-13 | — | — | US | disclosed |
| WO-2012080457-A1 | BICYCLIC RING SYSTEM SUBSTITUTED SULFONAMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316159-A1 | BICYCLIC RING SYSTEM SUBSTITUTED SULFONAMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS | CXCR2, CCR2, SULT2A1 | CXCR2 1/4885CCR6 51/4885CXCR1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.