Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | CLK1 | P49759 | 1/20 | 0.67 |
| ▸ | DPP4 | P27487 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | STAT3 | P40763 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | IDE | P14735 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9978015 | 0.88 | CCR5 (0.77) | CCR5SMN1; SMN2CLK1DPP4MEN1 | |
| SCHEMBL9978016 | 0.87 | CCR5 (0.75) | CCR5SMN1; SMN2CLK1DPP4MEN1 | |
| SCHEMBL9978046 | 0.86 | CCR5 (0.74) | CCR5SMN1; SMN2CLK1DPP4MEN1 | |
| SCHEMBL5579624 | 0.85 | CCR5 (0.84) | CCR5SMN1; SMN2CLK1DPP4MEN1 | |
| SCHEMBL5637725 | 0.84 | DRD2 (0.67) | CCR5SMN1; SMN2CLK1MEN1KMT2A | |
| SCHEMBL9977994 | 0.83 | MEN1 (0.87) | CCR5SMN1; SMN2CLK1MEN1KMT2A | |
| SCHEMBL5639453 | 0.83 | DRD2 (0.70) | CCR5SMN1; SMN2CLK1MAPTMAPK1 | |
| SCHEMBL27470403 | 0.82 | CYP3A4 (0.71) | CCR5SMN1; SMN2DPP4ALDH1A1 | |
| SCHEMBL5640554 | 0.81 | DRD2 (0.73) | CCR5SMN1; SMN2CLK1MAPTMAPK1 | |
| SCHEMBL5640194 | 0.80 | PDGFRB (0.83) | CLK1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012079164-A1 | ACTIVATORS OF CYLINDRICAL PROTEASES | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-06-21 | — | — | WO | disclosed |