⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10041202 | 0.83 | — | — | |
| SCHEMBL3422719 | 0.76 | — | — | |
| SCHEMBL10269800 | 0.74 | — | — | |
| SCHEMBL3422715 | 0.74 | — | — | |
| SCHEMBL18937106 | 0.74 | POLB (0.45) | — | |
| SCHEMBL3381684 | 0.74 | — | — | |
| SCHEMBL3913999 | 0.73 | ALDH1A1 (0.46) | — | |
| SCHEMBL777321 | 0.73 | ALDH1A1 (0.52) | — | |
| SCHEMBL12473129 | 0.72 | CYP2C19 (0.50) | — | |
| SCHEMBL16629061 | 0.72 | ALDH1A1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170260166-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ATIVIRAL AGENTS | JANSSEN INFECTIOUS DISEASES BVBA (BE) | 2017-09-14 | — | — | US | disclosed |
| US-9751888-B2 | Heterocyclic compounds and uses thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-9738652-B2 | Spiro urea compounds as RSV antiviral compounds | JANSSEN SCIENCES IRELAND UC (IE) | 2017-08-22 | — | — | US | disclosed |
| EP-2909195-B1 | RSV ANTIVIRAL COMPOUNDS | JANSSEN SCIENCES IRELAND UC (IE) | 2017-06-14 | — | — | EP | disclosed |
| US-20170044172-A1 | SPIRO UREA COMPOUNDS AS RSV ANTIVIRAL COMPOUNDS | JANSSEN INFECTIOUS DISEASES BVBA (BE) | 2017-02-16 | — | — | US | disclosed |
| EP-2948444-B1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-12-07 | — | — | EP | disclosed |
| US-20160237096-A1 | AZABENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-08-18 | — | — | US | disclosed |
| US-20160222016-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | TWELVE THERAPEUTICS, INC. | 2016-08-04 | — | — | US | disclosed |
| US-9321767-B2 | Azabenzimidazoles as respiratory syncytial virus antiviral agents | JANSSEN SCIENCES IRELAND UC (IE) | 2016-04-26 | — | — | US | disclosed |
| WO-2015051241-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2015-04-09 | — | — | WO | disclosed |
| US-20150073012-A1 | AZABENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2015-03-12 | — | — | US | disclosed |
| US-8927720-B2 | Azabenzimidazoles as respiratory syncytial virus antiviral agents | JANSSEN R&D IRELAND (IE) | 2015-01-06 | — | — | US | disclosed |
| US-8916574-B2 | 4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors | QILU PHARMACEUTICAL CO., LTD. (CN) | 2014-12-23 | — | — | US | disclosed |
| WO-2014114776-A1 | QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2014-07-31 | — | — | WO | disclosed |
| WO-2014060411-A1 | RSV ANTIVIRAL COMPOUNDS | JANSSEN R&D IRELAND (IE) | 2014-04-24 | — | — | WO | disclosed |
| US-20120208833-A1 | 4-(Substituted Anilino)-Quinazoline Derivatives Useful as Tyrosine Kinase Inhibitors | QILU PHARMACEUTICAL CO., LTD. (CN) | 2012-08-16 | — | — | US | disclosed |
| WO-2012080449-A1 | AZABENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2012-06-21 | — | — | WO | disclosed |