Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | RORA | P35398 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | RORB | Q92753 | 2/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2127732 | 0.89 | CNR1 (0.50) | CNR1PTGS2CNR2SCN5ASCN9A | |
| SCHEMBL4750454 | 0.88 | CNR1 (0.49) | CNR1PTGS2CNR2SCN5ASCN9A | |
| SCHEMBL9978231 | 0.88 | CNR1 (0.61) | CNR1PTGS2CNR2SCN5AMAPT | |
| SCHEMBL28013798 | 0.83 | CNR1 (0.45) | CNR1PTGS2CNR2SCN5ASCN9A | |
| SCHEMBL9932380 | 0.83 | CNR1 (0.52) | CNR1PTGS2CNR2SCN5ASCN9A | |
| SCHEMBL28013793 | 0.82 | CNR1 (0.42) | CNR1PTGS2CNR2SCN5ASCN9A | |
| SCHEMBL9931323 | 0.82 | CNR1 (0.51) | CNR1PTGS2CNR2SCN5ASCN9A | |
| SCHEMBL412159 | 0.82 | CNR1 (0.48) | CNR1PTGS2CNR2SCN5ASCN9A | |
| SCHEMBL9931686 | 0.82 | CNR1 (0.49) | CNR1PTGS2CNR2SCN5ASCN9A | |
| SCHEMBL9978227 | 0.81 | SLC6A3 (0.41) | CNR1PTGS2SCN5ASCN9ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012080144-A1 | OXIME COMPOUNDS AS HDL-CHOLESTEROL RAISING AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-06-21 | — | — | WO | disclosed |
| WO-2011029827-A1 | 5- (3, 4-DICHLORO-PHENYL) -N- (2-HYDROXY-CYCLOHEXYL) -6- (2,2, 2-TRIFLUORO-ETHOXY) -NICO TINAMIDE AND SALTS THEREOF AS HDL CHOLESTEROL RAISING AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-17 | — | — | WO | disclosed |