Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.34 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9572445 | 0.81 | KMT2A (0.58) | MEN1KMT2ASIRT2SIRT1SIRT3 | |
| SCHEMBL187133 | 0.78 | HCAR2 (0.54) | MEN1KMT2AHCAR2BCAT2KDM4E | |
| Methylamine SCHEMBL27659540 | 0.77 | LMNA (0.43) | MEN1KMT2AHCAR2KDM4E | |
| SCHEMBL28284702 | 0.77 | SIRT2 (0.54) | MEN1KMT2ASIRT2SIRT1SIRT3 | |
| SCHEMBL1921878 | 0.76 | LMNA (0.46) | MEN1KMT2AHCAR2KDM4ENPC1 | |
| SCHEMBL29225190 | 0.74 | KMT2A (0.45) | MEN1KMT2AKIF11SIRT6MKNK1 | |
| SCHEMBL28029118 | 0.74 | LMNA (0.45) | MEN1KMT2AHCAR2KDM4ENPC1 | |
| SCHEMBL283911 | 0.74 | KMT2A (0.55) | MEN1KMT2ASIRT2SIRT1SIRT3 | |
| SCHEMBL29786195 | 0.74 | KMT2A (0.55) | MEN1KMT2ASIRT2SIRT1SIRT3 | |
| SCHEMBL28940984 | 0.74 | APLNR (0.46) | MEN1KMT2AMKNK1MKNK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117813293-A | Urea derivatives useful for the treatment of cancer | 蝎子疗法股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115697978-A | Method for preparing methyl {4,6-diamino-2- [ 5-fluoro-1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b ] pyridin-3-yl ] pyrimidin-5-yl } carbamate | 阿德弗里奥药品有限责任公司 | 2023-02-03 | — | — | CN | disclosed |
| EP-2575473-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | Merck Sharp & Dohme Corp. (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011149921-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2011-12-01 | — | — | WO | disclosed |
| EP-0142040-A2 | Substituted pyrimidines | BAYER AG (DE) | 1985-05-22 | — | — | EP | disclosed |