Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1698081 | 0.89 | SLC6A2 (0.48) | GBA1SLC6A2TAAR1SIGMAR1LMNA | |
| SCHEMBL31336920 | 0.76 | SOS1 (0.47) | GBA1HRH1SLC6A2SLC6A4TAAR1 | |
| SCHEMBL9978781 | 0.76 | GBA1 (0.50) | GBA1HRH1SLC6A2SLC6A4TAAR1 | |
| SCHEMBL30670277 | 0.75 | GBA1 (0.35) | GBA1SLC6A4GABRA1 | |
| SCHEMBL5651523 | 0.75 | SLC6A2 (0.50) | GBA1HRH1SLC6A2SLC6A4TAAR1 | |
| SCHEMBL11861949 | 0.73 | HRH1 (0.53) | GBA1HRH1SLC6A2SLC6A4TAAR1 | |
| SCHEMBL2241250 | 0.73 | GBA1 (0.66) | GBA1SLC6A4KDM1AMAOBMAOA | |
| SCHEMBL87612 | 0.72 | GBA1 (1.00) | GBA1SLC6A4SLC18A3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL11843236 | 0.72 | HRH1 (0.51) | GBA1HRH1SLC6A2SLC6A4TAAR1 | |
| SCHEMBL27643138 | 0.72 | LMNA (0.49) | GBA1HRH1SLC6A2SLC6A4TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173170-A4 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-1173170-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2002-01-23 | — | — | EP | disclosed |
| US-6265434-B1 | ANTIINFLAMMATORY AGENTS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000059503-A1 | PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2000-10-12 | — | — | WO | disclosed |