Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 5/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | GAPDH | P04406 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199933 | 0.84 | GAPDH (0.71) | NPC1RAB9ASMN1; SMN2FLT3EGFR | |
| SCHEMBL13200780 | 0.84 | FLT3 (0.63) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9978507 | 0.83 | FLT3 (0.62) | NPC1RAB9AFLT3EGFRRET | |
| SCHEMBL1256800 | 0.83 | FLT3 (0.62) | NPC1RAB9APOLBFLT3EGFR | |
| SCHEMBL13199962 | 0.82 | RET (0.67) | NPC1RAB9AFLT3EGFRRET | |
| SCHEMBL13200383 | 0.81 | RET (0.62) | KMT2AMEN1NPC1RAB9AFLT3 | |
| SCHEMBL13200522 | 0.81 | FLT3 (0.69) | KMT2AMEN1NPC1RAB9AFLT3 | |
| SCHEMBL13200570 | 0.81 | FLT3 (0.60) | NPC1RAB9AFLT3EGFRRET | |
| SCHEMBL13199934 | 0.81 | KDM4E (0.71) | KMT2ASMN1; SMN2FLT3EGFRRET | |
| SCHEMBL2944790 | 0.81 | MAPK14 (0.69) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011150201-A2 | AZOLYL AMIDE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2011-12-01 | — | — | WO | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |