Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9978855 | 0.81 | AKR1B1 (0.36) | AKR1B1ALDH1A1TSHRHSD17B10CYP3A4 | |
| SCHEMBL11052254 | 0.78 | AKR1B1 (0.63) | AKR1B1ALDH1A1HSD17B10CYP3A4RECQL | |
| SCHEMBL5191843 | 0.77 | AKR1B1 (0.61) | AKR1B1ALDH1A1TSHRHSD17B10CYP3A4 | |
| SCHEMBL2366776 | 0.76 | AKR1B1 (0.39) | AKR1B1ALDH1A1TSHRHSD17B10CYP3A4 | |
| SCHEMBL5164705 | 0.76 | TPMT (0.39) | TSHRP2RX7TPMT | |
| SCHEMBL2211442 | 0.74 | IDO1 (0.53) | CYP3A4MAPK1P2RX7HPGDL3MBTL1 | |
| SCHEMBL31204467 | 0.74 | IDO1 (0.53) | CYP3A4MAPK1P2RX7HPGDL3MBTL1 | |
| SCHEMBL7617723 | 0.71 | AKR1B1 (0.39) | AKR1B1ALDH1A1TSHRHSD17B10CYP3A4 | |
| SCHEMBL320021 | 0.71 | TSHR (0.48) | ALDH1A1TSHRHSD17B10CYP3A4RECQL | |
| SCHEMBL5794837 | 0.68 | P2RX7 (0.45) | ALDH1A1TSHRHSD17B10CYP3A4RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576515-B1 | Pyrazolecarboxamide derivatives and their use as microbiocides | SYNGENTA PARTICIPATIONS AG (CH) | 2014-04-16 | — | — | EP | disclosed |
| EP-2576515-B1 | Pyrazolecarboxamide derivatives and their use as microbiocides | SYNGENTA PARTICIPATIONS AG (CH) | 2014-04-16 | — | — | EP | disclosed |
| WO-2013157651-A1 | PROCESS FOR PRODUCING ALPHA-HYDROXYKETONE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-10-24 | — | — | WO | disclosed |
| US-8552049-B2 | Pyrazolecarboxamide derivatives and their use as microbiocides | Syngenta Corp Protection, LLC (US) | 2013-10-08 | — | — | US | disclosed |
| US-8552049-B2 | Pyrazolecarboxamide derivatives and their use as microbiocides | Syngenta Corp Protection, LLC (US) | 2013-10-08 | — | — | US | disclosed |
| US-8552049-B2 | Pyrazolecarboxamide derivatives and their use as microbiocides | Syngenta Corp Protection, LLC (US) | 2013-10-08 | — | — | US | disclosed |
| EP-2576515-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | Syngenta Participations AG (CH) | 2013-04-10 | — | — | EP | disclosed |
| US-20130072535-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130072535-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130072535-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-03-21 | — | — | US | disclosed |
| WO-2011147690-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011147690-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072535-A1 | PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES | HRH4, MRGPRX4, C3AR1 | AKR1B1 1373/4885ALDH1A1 2869/4885TSHR 989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.