Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL279188 | 0.87 | MAPT (0.47) | MAPTLMNAGLO1KMT2ACTSK | |
| SCHEMBL275028 | 0.87 | MAPT (0.47) | MAPTLMNAGLO1KMT2ACTSK | |
| SCHEMBL275027 | 0.87 | MAPT (0.47) | MAPTLMNAGLO1KMT2ACTSK | |
| SCHEMBL692577 | 0.79 | KMT2A (0.60) | MAPTLMNAKMT2AALDH1A1PKM | |
| SCHEMBL16063547 | 0.77 | ITGB1 (0.48) | MAPTLMNAKMT2AALDH1A1PKM | |
| SCHEMBL10225345 | 0.76 | ATM (0.46) | GLO1CTSKCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL275672 | 0.75 | LMNA (0.50) | MAPTLMNAKMT2ACTSKALDH1A1 | |
| SCHEMBL1521502 | 0.75 | MAPT (0.44) | MAPTLMNAKMT2AALDH1A1PKM | |
| SCHEMBL10542296 | 0.74 | MAPT (0.38) | MAPTLMNAGLO1KMT2AALDH1A1 | |
| SCHEMBL10542304 | 0.74 | MAPT (0.38) | MAPTLMNAGLO1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2465505-A1 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | Bayer HealthCare LLC (US) | 2012-06-20 | — | — | EP | disclosed |