Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2706596 | 0.87 | PSEN1 (0.37) | CYP1A2SMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL2756587 | 0.85 | PSEN1 (0.39) | CYP1A2SMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL20055516 | 0.84 | PSEN1 (0.34) | CYP1A2SMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL13464853 | 0.84 | MAPT (0.44) | CYP1A2SMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL13070646 | 0.77 | MAPT (0.40) | CYP1A2SMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL2707211 | 0.72 | PSEN1 (0.41) | CYP1A2SMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL10391241 | 0.71 | ROS1 (0.59) | CYP1A2SMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL2707978 | 0.70 | HPGD (0.37) | CYP1A2SMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL13070648 | 0.70 | CYP1A2 (0.44) | CYP1A2SMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL17656232 | 0.69 | MAPT (0.40) | CYP1A2SMN1; SMN2NPC1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157404-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157404-A1 | ANTIVIRAL COMPOUNDS | MAVS, EIF2AK2, ZC3HAV1 | CYP1A2 3826/4885SMN1; SMN2 1564/4885NPC1 516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.