Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 7/20 | 0.42 |
| ▸ | CASP7 | P55210 | 7/20 | 0.42 |
| ▸ | CASP1 | P29466 | 4/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980385 | 0.89 | MAPT (0.44) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL12065552 | 0.87 | MAPT (0.44) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL9978263 | 0.85 | MAPT (0.58) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL12067050 | 0.85 | MAPT (0.46) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL12067173 | 0.79 | TNNI3K (0.56) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL9980388 | 0.79 | TNNI3K (0.56) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL9980516 | 0.75 | TNNI3K (0.56) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL12003831 | 0.75 | TNNI3K (0.56) | MAPTKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL9986945 | 0.75 | TNNI3K (0.49) | MAPTKDM4EALDH1A1HPGDCASP3 | |
| SCHEMBL9980398 | 0.74 | MAPT (0.60) | MAPTKDM4EALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |