Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 3/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 3/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12067173 | 1.00 | TNNI3K (0.56) | TNNI3KMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL9980516 | 0.83 | TNNI3K (0.56) | TNNI3KMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL12003831 | 0.83 | TNNI3K (0.56) | TNNI3KMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL12067991 | 0.81 | MAPT (0.66) | TNNI3KMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL12003680 | 0.81 | TNNI3K (0.53) | TNNI3KMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL12067050 | 0.80 | MAPT (0.46) | TNNI3KMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL9980429 | 0.79 | GAA (0.54) | MAPTKDM4EALDH1A1HPGDLMNA | |
| SCHEMBL9980386 | 0.79 | MAPT (0.45) | TNNI3KMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL2285629 | 0.78 | ALDH1A1 (0.47) | TNNI3KMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL12065552 | 0.78 | MAPT (0.44) | TNNI3KMAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |