Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 3/20 | 0.42 |
| ▸ | CASP3 | P42574 | 3/20 | 0.42 |
| ▸ | CASP7 | P55210 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9980398 | 0.90 | MAPT (0.60) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL9980458 | 0.88 | MAPT (0.60) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL9980400 | 0.86 | MAPT (0.63) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL9980386 | 0.85 | MAPT (0.45) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL12067991 | 0.80 | MAPT (0.66) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL12067109 | 0.76 | LMNA (0.61) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL9980385 | 0.74 | MAPT (0.44) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL12067935 | 0.74 | MAPT (0.67) | MAPTLMNAALDH1A1MEN1CYP1A2 | |
| SCHEMBL31022863 | 0.74 | LMNA (0.46) | MAPTLMNAALDH1A1MEN1CYP1A2 | |
| SCHEMBL9980389 | 0.73 | MAPT (0.69) | MAPTLMNAALDH1A1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2011149827-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2011-12-01 | — | — | WO | disclosed |