Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28063183 | 0.74 | POLB (0.59) | CNR1SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL20094688 | 0.73 | POLB (0.49) | SMN1; SMN2NPC1RAB9ATP53HTT | |
| SCHEMBL27696834 | 0.72 | MCHR1 (0.60) | SMN1; SMN2NPC1RAB9AMAPTPKM | |
| Ethane SCHEMBL6099926 | 0.70 | KDM4E (0.75) | SMN1; SMN2MAPTPKMHTTPOLB | |
| SCHEMBL15436573 | 0.70 | POLB (0.45) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| Ethane SCHEMBL6097475 | 0.68 | KDM4E (0.77) | SMN1; SMN2MAPTPKMHTTPOLB | |
| SCHEMBL12168064 | 0.68 | MAPT (0.48) | CNR1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL14503103 | 0.68 | NPSR1 (0.61) | SMN1; SMN2NPC1RAB9AMAPTPTPN11 | |
| SCHEMBL4251987 | 0.67 | RAB9A (0.85) | SMN1; SMN2NPC1RAB9AMAPTPKM | |
| Ethane SCHEMBL6097843 | 0.67 | MAPT (0.54) | MAPTTP53ADORA3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627650-A2 | N-PHENYL IMIDAZOLE CARBOXAMIDE INHIBITORS OF 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | Merck Sharp & Dohme Corp. (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2011149874-A2 | N-PHENYL IMIDAZOLE CARBOXAMIDE INHIBITORS OF 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | SCHERING CORPORATION (US) | 2011-12-01 | — | — | WO | disclosed |