Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15436508 | 0.86 | KMT2A (0.46) | RAB9ASMN1; SMN2NPC1TP53LMNA | |
| SCHEMBL28063183 | 0.78 | POLB (0.59) | POLBRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL20094688 | 0.77 | POLB (0.49) | POLBRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL15436746 | 0.77 | CSF1R (0.41) | RAB9ASMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL15436493 | 0.77 | CSF1R (0.40) | RAB9ASMN1; SMN2NPC1TP53ALDH1A1 | |
| SCHEMBL19868327 | 0.76 | CREBBP (0.35) | POLBSMN1; SMN2TSHRHTTHPGD | |
| SCHEMBL1863248 | 0.76 | PIN1 (0.39) | LMNA | |
| SCHEMBL15436762 | 0.73 | CSF1R (0.41) | POLBRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL25293709 | 0.70 | HPSE (0.36) | POLBRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL9980598 | 0.70 | CNR1 (0.49) | POLBRAB9ASMN1; SMN2NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215079-B1 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2016-12-14 | — | — | EP | disclosed |
| EP-2687516-A1 | Inhibitors of C-FMS Kinase | Janssen Pharmaceutica N.V. (BE) | 2014-01-22 | — | — | EP | disclosed |