Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 19/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15489130 | 0.91 | SLC18A3 (0.61) | SLC18A3DRD2POLB | |
| SCHEMBL9980735 | 0.84 | SLC18A3 (0.62) | SLC18A3DRD2 | |
| SCHEMBL230405 | 0.78 | NPC1 (0.71) | POLB | |
| SCHEMBL12031776 | 0.78 | SLC18A3 (0.75) | SLC18A3 | |
| Hydrochloric Acid SCHEMBL518416 | 0.77 | KMT2A (0.69) | POLB | |
| Bromide SCHEMBL7247705 | 0.77 | NPC1 (0.69) | POLB | |
| SCHEMBL9980692 | 0.76 | SLC18A3 (1.00) | SLC18A3DRD2 | |
| SCHEMBL9980908 | 0.75 | SLC18A3 (1.00) | SLC18A3POLB | |
| SCHEMBL15489129 | 0.75 | SLC18A3 (0.61) | SLC18A3DRD2 | |
| SCHEMBL9980727 | 0.74 | SLC18A3 (0.83) | SLC18A3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8658131-B2 | Compounds comprising 4-benzoylpiperidine as a sigma-1-selective ligand | WASHINGTON UNIVERSITY (US) | 2014-02-25 | — | — | US | disclosed |
| US-8658131-B2 | Compounds comprising 4-benzoylpiperidine as a sigma-1-selective ligand | WASHINGTON UNIVERSITY (US) | 2014-02-25 | — | — | US | disclosed |
| US-20110311447-A1 | Compounds comprising 4-benzoylpiperidine as a Sigma-1-selective ligand | WASHINGTON UNIVERSITY (US) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110311447-A1 | Compounds comprising 4-benzoylpiperidine as a Sigma-1-selective ligand | SIGMAR1, TMEM97, OPRM1 | SLC18A3 248/4885DRD2 25/4885POLB 2221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.