Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998153 | 0.82 | MEN1 (0.32) | MEN1GAARAB9AKMT2A | |
| SCHEMBL1050370 | 0.78 | NPC1 (0.33) | MEN1GAARAB9AKMT2A | |
| SCHEMBL3705796 | 0.71 | L3MBTL1 (0.33) | — | |
| SCHEMBL3706155 | 0.70 | GRM4 (0.42) | MEN1RAB9AKMT2A | |
| SCHEMBL3703227 | 0.66 | TGFBR1 (0.36) | MEN1RAB9AKMT2A | |
| SCHEMBL998005 | 0.66 | GRM5 (0.43) | MEN1RAB9AKMT2A | |
| SCHEMBL15049595 | 0.61 | CCR1 (0.31) | — | |
| SCHEMBL14082025 | 0.60 | CCR1 (0.52) | MEN1RAB9AKMT2AHTR3A | |
| SCHEMBL18074325 | 0.59 | — | — | |
| SCHEMBL1052153 | 0.59 | IRAK4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456769-A1 | NOVEL PYRAZOLE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011010222-A1 | NOVEL PYRAZOLE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2011-01-27 | — | — | WO | disclosed |