Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | MC4R | P32245 | 4/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998155 | 1.00 | HTR7 (0.41) | HTR7HTR6HTR1ADRD2HTR2A | |
| SCHEMBL996959 | 0.81 | HTR7 (0.47) | HTR7HTR6HTR1ADRD2HTR2A | |
| SCHEMBL1079190 | 0.81 | HTR7 (0.39) | HTR7HTR6HTR1ADRD2HTR2A | |
| SCHEMBL1079194 | 0.81 | HTR7 (0.39) | HTR7HTR6HTR1ADRD2HTR2A | |
| SCHEMBL996958 | 0.81 | HTR7 (0.47) | HTR7HTR6HTR1ADRD2HTR2A | |
| SCHEMBL995904 | 0.79 | HTR7 (0.38) | HTR7HTR6HTR1ADRD2HTR2A | |
| SCHEMBL1002884 | 0.76 | CYP1A2 (0.42) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL1002885 | 0.76 | CYP1A2 (0.42) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL997427 | 0.74 | TP53 (0.39) | — | |
| SCHEMBL997429 | 0.74 | TP53 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456436-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | Theravance, Inc. (US) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011011231-A1 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-01-27 | — | — | WO | disclosed |