Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Morpholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL27288614 | 0.90 | MEN1 (0.39) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL1508329 | 0.90 | MEN1 (0.39) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Sulfuric Acid Dimethyl Ester SCHEMBL6560200 | 0.84 | MEN1 (0.50) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL11598859 | 0.84 | MEN1 (0.50) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL11598863 | 0.84 | MEN1 (0.50) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL28072684 | 0.84 | MEN1 (0.50) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL9393876 | 0.83 | MEN1 (0.55) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL2808231 | 0.83 | MEN1 (0.61) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL2808233 | 0.83 | MEN1 (0.61) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Piperazine SCHEMBL27656709 | 0.83 | TSHR (0.40) | LMNACYP3A4GABRA1TSHRGABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11701308-B2 | Compositions for coloring hair including ultra-efficient high aqueous, multi-lamellar emulsion systems, and methods of making the same | COMBE INCORPORATED (US) | 2023-07-18 | — | — | US | disclosed |
| EP-4117609-A1 | COMPOSITIONS FOR COLORING HAIR INCLUDING ULTRA-EFFICIENT HIGH AQUEOUS, MULTI-LAMELLAR EMULSION SYSTEMS, AND METHODS OF MAKING THE SAME | Combe International LLC (US) | 2023-01-18 | — | — | EP | disclosed |
| CN-108473484-B | Compounds useful as TRPM8 modulators | 弗门尼舍公司 | 2021-06-29 | — | — | CN | disclosed |
| CN-108341788-A | A kind of mosapride citrate intermediate and purposes | 鲁南制药集团股份有限公司 | 2018-07-31 | — | — | CN | disclosed |
| EP-2394630-A2 | Cosmetic compound for colouring hair with a direct dye and a lipid vesicle vehicle system | ROVI Cosmetics International GmbH (DE) | 2011-12-14 | — | — | EP | disclosed |
| EP-2394629-A2 | Cosmetic composition for colouring hair with a direct dye and a polysaccharide vehicle system | ROVI Cosmetics International GmbH (DE) | 2011-12-14 | — | — | EP | disclosed |