Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.68 |
| ▸ | RAB9A | P51151 | 10/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | CDK1 | P06493 | 1/20 | 0.68 |
| ▸ | CDK2 | P24941 | 1/20 | 0.68 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.68 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.66 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | PKM | P14618 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530312 | 0.82 | CDK1 (0.69) | NPC1RAB9ACDK1CDK2MKNK1 | |
| SCHEMBL19960361 | 0.82 | NPC1 (0.72) | NPC1RAB9AMEN1KMT2ACDK1 | |
| SCHEMBL18891696 | 0.82 | NPC1 (0.68) | NPC1RAB9AMEN1KMT2ACDK1 | |
| SCHEMBL3090064 | 0.81 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2ACDK1 | |
| SCHEMBL222463 | 0.81 | CDK1 (1.00) | NPC1RAB9ACDK1CDK2MKNK1 | |
| SCHEMBL28036109 | 0.81 | CDK1 (0.68) | NPC1RAB9ACDK1CDK2MKNK1 | |
| SCHEMBL30874471 | 0.81 | CDK1 (1.00) | NPC1RAB9ACDK1CDK2MKNK1 | |
| SCHEMBL227743 | 0.80 | NPC1 (0.78) | NPC1RAB9ACDK1CDK2MKNK1 | |
| SCHEMBL162191 | 0.80 | NPC1 (1.00) | NPC1RAB9ACDK1CDK2MKNK1 | |
| SCHEMBL29695905 | 0.80 | NPC1 (1.00) | NPC1RAB9ACDK1CDK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273080-B2 | Metal complexes | MEREK PATENT GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-20130082209-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2013-04-04 | — | — | US | disclosed |
| WO-2011157339-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2011-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130082209-A1 | METAL COMPLEXES | MCOLN2, MCOLN1, AP1M1 | NPC1 1682/4885RAB9A 1404/4885MEN1 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.