Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.55 |
| ▸ | JAK1 | P23458 | 4/20 | 0.55 |
| ▸ | TYK2 | P29597 | 2/20 | 0.55 |
| ▸ | JAK3 | P52333 | 2/20 | 0.55 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | BCL9 | O00512 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502653 | 0.83 | JAK2 (0.57) | JAK2JAK1TYK2JAK3USP30 | |
| SCHEMBL9986596 | 0.81 | USP30 (0.56) | JAK2JAK1TYK2JAK3USP30 | |
| SCHEMBL29806002 | 0.81 | USP30 (0.56) | JAK2JAK1TYK2JAK3USP30 | |
| SCHEMBL46733 | 0.81 | PREP (0.50) | — | |
| SCHEMBL29087342 | 0.80 | SMN1; SMN2 (0.59) | JAK2JAK1TYK2JAK3SMN1; SMN2 | |
| SCHEMBL9986277 | 0.78 | JAK2 (0.59) | JAK2JAK1TYK2JAK3USP30 | |
| SCHEMBL29806318 | 0.77 | JAK2 (0.52) | JAK2JAK1TYK2JAK3USP30 | |
| SCHEMBL29080164 | 0.77 | JAK2 (0.52) | JAK2JAK1TYK2JAK3USP30 | |
| SCHEMBL13490506 | 0.76 | JAK2 (0.55) | JAK2JAK1TYK2JAK3USP30 | |
| SCHEMBL5368396 | 0.76 | SMN1; SMN2 (0.60) | JAK2JAK1TYK2JAK3USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |
| US-8080566-B1 | Carbazole inhibitors of histamine receptors for the treatment of disease | KALYPSYS, INC (US) | 2011-12-20 | — | — | US | disclosed |