Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959878 | 0.89 | MAPK1 (0.52) | MAPK1 | |
| SCHEMBL15249631 | 0.84 | MAOB (0.43) | MAPK1 | |
| SCHEMBL30864308 | 0.84 | HCAR2 (0.45) | — | |
| SCHEMBL9986667 | 0.82 | SMO (0.49) | MAPK1 | |
| SCHEMBL30040852 | 0.82 | SMO (0.49) | MAPK1 | |
| SCHEMBL21725159 | 0.82 | IRAK4 (0.43) | — | |
| SCHEMBL1667310 | 0.81 | PLA2G10 (0.55) | — | |
| SCHEMBL121760 | 0.81 | KHK (0.55) | — | |
| SCHEMBL2610311 | 0.79 | MGLL (0.57) | — | |
| SCHEMBL30864253 | 0.79 | CYP11B2 (0.63) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2584903-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011163330-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-12-29 | — | — | WO | disclosed |