Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 9/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987206 | 1.00 | CA12 (0.37) | CA12CA1CA9HSP90AA1HSP90AB1 | |
| SCHEMBL9987962 | 0.85 | GPBAR1 (0.46) | CA12CA1CA9HSP90AA1HSP90AB1 | |
| SCHEMBL9987966 | 0.85 | GPBAR1 (0.46) | CA12CA1CA9HSP90AA1HSP90AB1 | |
| SCHEMBL9987742 | 0.85 | MTNR1A (0.36) | CA12CA1CA9HSP90AA1HSP90AB1 | |
| SCHEMBL13219091 | 0.84 | OGG1 (0.42) | — | |
| SCHEMBL9987262 | 0.82 | CA12 (0.42) | CA12CA1CA9HSP90AA1HSP90AB1 | |
| SCHEMBL7706827 | 0.79 | CA1 (0.50) | CA12CA1CA9HSP90AA1HSP90AB1 | |
| SCHEMBL22233852 | 0.78 | KDM4E (0.36) | PREP | |
| SCHEMBL9987844 | 0.77 | CA12 (0.38) | CA12CA1CA9HSP90AA1HSP90AB1 | |
| SCHEMBL9987417 | 0.75 | FFAR1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |