Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 7/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | AGXT | P21549 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987222 | 0.83 | CNR1 (0.44) | MAOBAPPCNR2CNR1PIN1 | |
| SCHEMBL22323930 | 0.82 | APP (0.50) | MAOBAPPCNR2CNR1PIN1 | |
| SCHEMBL3196355 | 0.82 | CNR1 (0.43) | MAOBAPPCNR2CNR1PIN1 | |
| SCHEMBL846643 | 0.82 | POLB (0.47) | MAOBAPPCNR2CNR1PIN1 | |
| SCHEMBL31514820 | 0.82 | CNR1 (0.43) | MAOBAPPCNR2CNR1PIN1 | |
| SCHEMBL9987933 | 0.81 | PIN1 (0.44) | MAOBAPPCNR2CNR1PIN1 | |
| SCHEMBL20564303 | 0.80 | MAOB (0.43) | MAOBAPPCNR2CNR1HRH4 | |
| SCHEMBL20565236 | 0.78 | AR (0.43) | MAOBAPPCNR2CNR1PIN1 | |
| SCHEMBL20564322 | 0.78 | CNR2 (0.43) | MAOBAPPCNR2CNR1HRH4 | |
| SCHEMBL20564007 | 0.77 | HTR6 (0.40) | MAOBAPPCNR2CNR1PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |