Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.42 |
| ▸ | TTR | P02766 | 2/20 | 0.39 |
| ▸ | ALB | P02768 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 5/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467430 | 0.88 | TTR (0.38) | MGLLTTRALBMEN1KMT2A | |
| SCHEMBL12127948 | 0.86 | TTR (0.37) | MGLLTTRALBMEN1KMT2A | |
| SCHEMBL5233624 | 0.84 | ALDH1A1 (0.42) | MEN1KMT2AKAT6ACA12CA2 | |
| SCHEMBL23072580 | 0.81 | ALDH1A1 (0.44) | MGLLKAT6AALDH1A1 | |
| SCHEMBL10768894 | 0.80 | CA12 (0.45) | MEN1KMT2ACA12CA2CA9 | |
| SCHEMBL12127900 | 0.79 | MGLL (0.42) | MGLLTTRALBKAT6AALDH1A1 | |
| SCHEMBL1344294 | 0.79 | ALDH1A1 (0.46) | TTRALBMEN1KMT2ACA2 | |
| SCHEMBL12127371 | 0.78 | KCNH2 (0.43) | MGLLSCN2ASCN10AGAASMN1; SMN2 | |
| SCHEMBL2656346 | 0.78 | TTR (0.35) | MGLLTTRALBMEN1KMT2A | |
| SCHEMBL12332162 | 0.78 | GRIN2D (0.33) | MGLLTTRALBGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |