Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL969052 | 0.81 | ALDH1A1 (0.31) | ALDH1A1TP53MEN1KMT2A | |
| SCHEMBL27401647 | 0.66 | ALOX15 (0.39) | MAPK1ALOX15L3MBTL1ALDH1A1TP53 | |
| SCHEMBL969584 | 0.62 | CDC7 (0.44) | ALDH1A1MEN1KMT2A | |
| SCHEMBL973138 | 0.61 | GAA (0.31) | — | |
| SCHEMBL972774 | 0.59 | CA12 (0.38) | ALDH1A1MEN1KMT2A | |
| SCHEMBL969682 | 0.59 | CYP2C9 (0.34) | L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL24042812 | 0.59 | MAPT (0.40) | ALOX15ALDH1A1NPSR1MEN1KMT2A | |
| SCHEMBL13434171 | 0.58 | SLC6A4 (0.36) | ALDH1A1 | |
| SCHEMBL971864 | 0.58 | ALDH1A1 (0.31) | ALDH1A1TP53NPSR1 | |
| SCHEMBL8889427 | 0.57 | ALDH1A1 (0.40) | L3MBTL1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582706-A1 | 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011157682-A1 | 3-OXO-3,9-DIHYDRO-1H-CHROMENO[2,3-C]PYRROLES AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-22 | — | — | WO | disclosed |