Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | RHOA | P61586 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984137 | 0.92 | BRD4 (0.50) | BRD4NTRK1MAPTMAPK1POLB | |
| SCHEMBL9984423 | 0.91 | BRD4 (0.53) | BRD4NTRK1KMT2AMAPTMEN1 | |
| SCHEMBL9987376 | 0.91 | TDP1 (0.48) | BRD4TDP1SERPINE1JAK2KMT2A | |
| SCHEMBL9987060 | 0.89 | TDP1 (0.43) | BRD4TDP1SERPINE1JAK2KMT2A | |
| SCHEMBL9983765 | 0.89 | BRD4 (0.53) | BRD4NTRK1MAPTMAPK1CYP2C9 | |
| SCHEMBL9984854 | 0.88 | BRD4 (0.57) | BRD4NTRK1MAPTMAPK1CYP2C9 | |
| SCHEMBL9987013 | 0.86 | TDP1 (0.39) | BRD4TDP1SERPINE1JAK2RET | |
| SCHEMBL9984657 | 0.85 | BRD4 (0.48) | BRD4NTRK1KMT2AMAPTMEN1 | |
| SCHEMBL9984381 | 0.85 | BRD4 (0.57) | BRD4NTRK1MAPTMAPK1GAA | |
| SCHEMBL9985174 | 0.85 | BRD4 (0.55) | BRD4NTRK1MAPTCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394993-A2 | NOVEL 2,6-SUBSTITUTED-3-NITROPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | Dong Wha Pharm. Co., Ltd. (KR) | 2011-12-14 | — | — | EP | disclosed |