Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 7/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 7/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | ROS1 | P08922 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | MTTP | P55157 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984105 | 0.94 | MAPT (0.41) | BRD4NPY2RRETROS1FLT3 | |
| SCHEMBL9984092 | 0.87 | ALDH1A1 (0.41) | BRD4NPY2RRETROS1FLT3 | |
| SCHEMBL9987584 | 0.86 | BRD4 (0.51) | TDP1BRD4SERPINE1JAK2RET | |
| SCHEMBL9983513 | 0.83 | TP53 (0.39) | BRD4 | |
| SCHEMBL9987376 | 0.83 | TDP1 (0.48) | TDP1BRD4SERPINE1JAK2RET | |
| SCHEMBL9987060 | 0.82 | TDP1 (0.43) | TDP1BRD4SERPINE1JAK2RET | |
| SCHEMBL9987009 | 0.81 | L3MBTL1 (0.46) | TDP1BRD4SERPINE1JAK2RET | |
| SCHEMBL9987164 | 0.81 | TDP1 (0.42) | TDP1BRD4SERPINE1JAK2RET | |
| SCHEMBL9984137 | 0.79 | BRD4 (0.50) | BRD4RETROS1FLT3EML4 | |
| SCHEMBL9987425 | 0.78 | MAPT (0.44) | TDP1SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394993-A2 | NOVEL 2,6-SUBSTITUTED-3-NITROPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | Dong Wha Pharm. Co., Ltd. (KR) | 2011-12-14 | — | — | EP | disclosed |