Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 5/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984009 | 0.92 | MAPT (0.50) | TDP1HSF1BRD4MAPTMAPK1 | |
| SCHEMBL9987584 | 0.91 | BRD4 (0.51) | TDP1BRD4SERPINE1JAK2KMT2A | |
| SCHEMBL9984171 | 0.90 | HSF1 (0.49) | HSF1BRD4KMT2AMAPTMEN1 | |
| SCHEMBL9987060 | 0.88 | TDP1 (0.43) | TDP1BRD4SERPINE1JAK2KMT2A | |
| SCHEMBL9984060 | 0.88 | HSF1 (0.49) | HSF1BRD4MAPTMAPK1L3MBTL1 | |
| SCHEMBL9987980 | 0.87 | TDP1 (0.49) | TDP1BRD4SERPINE1JAK2KMT2A | |
| SCHEMBL9984372 | 0.86 | HSF1 (0.53) | HSF1BRD4KMT2AMAPTMAPK1 | |
| SCHEMBL9987975 | 0.85 | FLT3 (0.46) | TDP1BRD4SERPINE1JAK2KMT2A | |
| SCHEMBL9987164 | 0.85 | TDP1 (0.42) | TDP1BRD4SERPINE1JAK2KMT2A | |
| SCHEMBL9988152 | 0.85 | TDP1 (0.47) | TDP1BRD4SERPINE1JAK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394993-A2 | NOVEL 2,6-SUBSTITUTED-3-NITROPYRIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | Dong Wha Pharm. Co., Ltd. (KR) | 2011-12-14 | — | — | EP | disclosed |