Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MYOC | Q99972 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4481847 | 0.86 | HSPB1 (0.47) | HSPB1MEN1KMT2AALDH1A1SOS1 | |
| SCHEMBL4282427 | 0.83 | KDM4E (0.48) | HSPB1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL364168 | 0.81 | HSPB1 (1.00) | HSPB1MEN1KMT2AALDH1A1SOS1 | |
| SCHEMBL15911431 | 0.80 | HSPB1 (0.71) | HSPB1MEN1KMT2AALDH1A1SOS1 | |
| SCHEMBL4380440 | 0.79 | HSPB1 (0.69) | HSPB1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9685496 | 0.77 | HSPB1 (0.41) | HSPB1MEN1KMT2AALDH1A1SOS1 | |
| SCHEMBL15911443 | 0.76 | HSPB1 (0.65) | HSPB1MEN1KMT2AALDH1A1SOS1 | |
| SCHEMBL4481437 | 0.76 | MEN1 (0.68) | HSPB1MEN1KMT2AALDH1A1SOS1 | |
| SCHEMBL22686984 | 0.76 | HSPB1 (0.65) | HSPB1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL28928700 | 0.74 | HTR2A (0.40) | HSPB1MEN1KMT2AALDH1A1SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2397462-A2 | Compounds, compositions and methods of treatment for heart failure | Cytokinetics, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |
| CN-100345823-C | Compounds, compositions and methods | CYTOKINETICS INC (US) | 2007-10-31 | — | — | CN | disclosed |
| CN-1738793-A | Compounds, compositions and methods | CYTOKINETICS INC (US) | 2006-02-22 | — | — | CN | disclosed |