Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 4/20 | 0.47 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9987740 | 0.86 | HSPB1 (0.67) | HSPB1SOS1ALDH1A1CRHBPCRHR2 | |
| SCHEMBL6031667 | 0.84 | CA1 (0.33) | HSPB1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL6029387 | 0.84 | MAPT (0.42) | HSPB1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL1720258 | 0.84 | LTA4H (0.40) | SOS1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL1718985 | 0.76 | MAPT (0.53) | ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL9685496 | 0.76 | HSPB1 (0.41) | HSPB1SOS1SCN4ACYP1A2CYP2C19 | |
| SCHEMBL4477201 | 0.74 | LMNA (0.56) | CYP1A2CYP2C19CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL1719599 | 0.73 | LMNA (0.34) | ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL28928700 | 0.73 | HTR2A (0.40) | HSPB1SOS1SCN4ASCN9AHPGD | |
| SCHEMBL4282427 | 0.69 | KDM4E (0.48) | HSPB1CYP1A2CYP2C9HPGDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503986-B1 | COMPOSITIONS AND METHODS FOR TREATING HEART FAILURE | CYTOKINETICS INC (US) | 2015-09-30 | — | — | EP | claimed |
| US-7605164-B2 | Compositions and methods for treating heart failure | CYTOKINETICS, INC. (US) | 2009-10-20 | — | — | US | claimed |